{"id":10975,"date":"2025-06-28T00:10:01","date_gmt":"2025-06-27T16:10:01","guid":{"rendered":"https:\/\/www.51malin.com\/index.php\/archives\/10975"},"modified":"2025-06-28T00:10:01","modified_gmt":"2025-06-27T16:10:01","slug":"%e5%af%b9%e6%af%94dbu%e4%b8%8e%e5%85%b6%e4%bb%96%e5%b8%b8%e7%94%a8%e8%83%ba%e7%b1%bb%e5%82%ac%e5%8c%96%e5%89%82%e7%9a%84%e5%82%ac%e5%8c%96%e6%b4%bb%e6%80%a7%e5%92%8c%e9%80%89%e6%8b%a9%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.51malin.com\/index.php\/archives\/10975","title":{"rendered":"\u5bf9\u6bd4DBU\u4e0e\u5176\u4ed6\u5e38\u7528\u80fa\u7c7b\u50ac\u5316\u5242\u7684\u50ac\u5316\u6d3b\u6027\u548c\u9009\u62e9\u6027"},"content":{"rendered":"<h3>DBU\u4e0e\u5176\u4ed6\u5e38\u7528\u80fa\u7c7b\u50ac\u5316\u5242\u7684\u50ac\u5316\u6d3b\u6027\u4e0e\u9009\u62e9\u6027\u5bf9\u6bd4\u7814\u7a76<\/h3>\n<p>\u5728\u6709\u673a\u5408\u6210\u7684\u4e16\u754c\u91cc\uff0c\u50ac\u5316\u5242\u5c31\u50cf\u662f\u4e00\u7fa4\u201c\u5316\u5b66\u9b54\u672f\u5e08\u201d\uff0c\u5b83\u4eec\u4e0d\u53c2\u4e0e\u53cd\u5e94\u672c\u8eab\uff0c\u5374\u80fd\u8ba9\u53cd\u5e94\u53d8\u5f97\u66f4\u5feb\u3001\u66f4\u9ad8\u6548\u3001\u66f4\u6709\u9009\u62e9\u6027\u3002\u800c\u5728\u8fd9\u4e9b\u201c\u9b54\u6cd5\u5e08\u201d\u4e2d\uff0cDBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09\u65e0\u7591\u662f\u4e00\u4e2a\u975e\u5e38\u7279\u522b\u7684\u5b58\u5728\u3002\u5b83\u4e0d\u50cf\u4f20\u7edf\u7684\u80fa\u7c7b\u50ac\u5316\u5242\u90a3\u6837\u201c\u5faa\u89c4\u8e48\u77e9\u201d\uff0c\u800c\u662f\u5e26\u7740\u4e00\u79cd\u72ec\u7279\u7684\u201c\u4e2a\u6027\u201d\uff0c\u5728\u67d0\u4e9b\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u4ee4\u4eba\u60ca\u53f9\u7684\u50ac\u5316\u80fd\u529b\u548c\u9009\u62e9\u6027\u3002<\/p>\n<p>\u4eca\u5929\uff0c\u6211\u4eec\u5c31\u6765\u804a\u804aDBU\u8fd9\u4f4d\u201c\u53e6\u7c7b\u201d\u7684\u80fa\u7c7b\u50ac\u5316\u5242\uff0c\u770b\u770b\u5b83\u548c\u5176\u4ed6\u5e38\u89c1\u7684\u80fa\u7c7b\u50ac\u5316\u5242\u76f8\u6bd4\uff0c\u5230\u5e95\u6709\u54ea\u4e9b\u4e0d\u540c\u4e4b\u5904\uff0c\u53c8\u4e3a\u4f55\u80fd\u5728\u67d0\u4e9b\u573a\u5408\u8131\u9896\u800c\u51fa\u3002<\/p>\n<hr \/>\n<h2>\u4e00\u3001DBU\u662f\u8c01\uff1f\u5b83\u7684\u57fa\u672c\u53c2\u6570\u548c\u7279\u70b9<\/h2>\n<p>DBU\u7684\u5168\u79f0\u662f1,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff0c\u5206\u5b50\u5f0f\u4e3aC9H16N2\uff0c\u5206\u5b50\u91cf\u7ea6\u4e3a152.24 g\/mol\u3002\u5b83\u662f\u4e00\u79cd\u65e0\u8272\u81f3\u6de1\u9ec4\u8272\u7684\u6db2\u4f53\uff0c\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\u548c\u826f\u597d\u7684\u70ed\u7a33\u5b9a\u6027\u3002DBU\u7684pKa\u503c\u7ea6\u4e3a13.5\uff0c\u5728\u6709\u673a\u6eb6\u5242\u4e2d\u6709\u8f83\u597d\u7684\u6eb6\u89e3\u6027\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u6781\u6027\u975e\u8d28\u5b50\u6eb6\u5242\u5982DMF\u3001DMSO\u7b49\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53c2\u6570<\/th>\n<th>\u6570\u503c\u6216\u63cf\u8ff0<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C9H16N2<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>152.24 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u89c2<\/td>\n<td>\u65e0\u8272\u81f3\u6de1\u9ec4\u8272\u6db2\u4f53<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>-75\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u6cb8\u70b9<\/td>\n<td>225\u2013227\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>pKa<\/td>\n<td>~13.5<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u53ef\u6eb6\u4e8e\u591a\u6570\u6709\u673a\u6eb6\u5242<\/td>\n<\/tr>\n<tr>\n<td>\u50ac\u5316\u7c7b\u578b<\/td>\n<td>\u5f31\u4eb2\u6838\u6027\u5f3a\u78b1\u6027<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>DBU\u7684\u72ec\u7279\u7ed3\u6784\u8d4b\u4e88\u4e86\u5b83\u4e0e\u4f17\u4e0d\u540c\u7684\u6027\u8d28\u3002\u5b83\u7684\u4e24\u4e2a\u6c2e\u539f\u5b50\u5904\u4e8e\u4e00\u4e2a\u521a\u6027\u7684\u53cc\u73af\u7ed3\u6784\u4e2d\uff0c\u4f7f\u5f97\u5176\u78b1\u6027\u8f83\u5f3a\u4f46\u4eb2\u6838\u6027\u8f83\u5f31\u3002\u8fd9\u79cd\u7279\u6027\u8ba9\u5b83\u5728\u5f88\u591a\u9700\u8981\u78b1\u6027\u73af\u5883\u4f46\u53c8\u4e0d\u5e0c\u671b\u53d1\u751f\u526f\u53cd\u5e94\u7684\u53cd\u5e94\u4e2d\u8868\u73b0\u4f18\u5f02\u3002<\/p>\n<hr \/>\n<h2>\u4e8c\u3001\u5e38\u89c1\u7684\u80fa\u7c7b\u50ac\u5316\u5242\u90fd\u6709\u54ea\u4e9b\uff1f<\/h2>\n<p>\u5728\u6709\u673a\u5408\u6210\u4e2d\uff0c\u5e38\u7528\u7684\u80fa\u7c7b\u50ac\u5316\u5242\u4e3b\u8981\u5305\u62ec\u4ee5\u4e0b\u51e0\u7c7b\uff1a<\/p>\n<ol>\n<li><strong>\u4e09\u4e59\u80fa\uff08TEA\uff09<\/strong>\uff1a\u57fa\u7840\u4e5f\u662f\u5e38\u89c1\u7684\u6709\u673a\u78b1\u4e4b\u4e00\uff0c\u5e7f\u6cdb\u7528\u4e8e\u916f\u5316\u3001\u9170\u5316\u7b49\u53cd\u5e94\u3002<\/li>\n<li><strong>DIPEA\uff08N,N-\u4e8c\u5f02\u4e19\u57fa\u4e59\u80fa\uff09<\/strong>\uff1a\u6bd4TEA\u66f4\u5f3a\u7684\u78b1\uff0c\u5e38\u7528\u4e8e\u80bd\u5076\u8054\u53cd\u5e94\u3002<\/li>\n<li><strong>DBN\uff081,5-\u4e8c\u6c2e\u6742\u53cc\u73af[4.3.0]\u58ec-5-\u70ef\uff09<\/strong>\uff1a\u7ed3\u6784\u4e0a\u4e0eDBU\u7c7b\u4f3c\uff0c\u4f46\u73af\u5927\u5c0f\u4e0d\u540c\u3002<\/li>\n<li><strong>TMEDA\uff08N,N,N&#8217;,N&#8217;-\u56db\u7532\u57fa\u4e59\u4e8c\u80fa\uff09<\/strong>\uff1a\u4e3b\u8981\u7528\u4e8e\u91d1\u5c5e\u50ac\u5316\u7684\u53cd\u5e94\u4e2d\u4f5c\u4e3a\u914d\u4f53\u3002<\/li>\n<li><strong>LDA\uff08\u4e8c\u5f02\u4e19\u57fa\u6c28\u57fa\u9502\uff09<\/strong>\uff1a\u5f3a\u78b1\uff0c\u5e38\u7528\u4e8e\u53bb\u8d28\u5b50\u5316\u53cd\u5e94\u3002<\/li>\n<li><strong>\u3001\u5421\u5576\u53ca\u5176\u884d\u751f\u7269<\/strong>\uff1a\u5e38\u89c1\u4e8e\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u548c\u6210\u76d0\u53cd\u5e94\u4e2d\u3002<\/li>\n<\/ol>\n<p>\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u4e00\u5f20\u8868\u683c\u6765\u770b\u770b\u8fd9\u4e9b\u50ac\u5316\u5242\u7684\u4e00\u4e9b\u57fa\u672c\u6027\u80fd\u6bd4\u8f83\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\u50ac\u5316\u5242\u540d\u79f0<\/th>\n<th>\u5206\u5b50\u5f0f<\/th>\n<th>\u5206\u5b50\u91cf(g\/mol)<\/th>\n<th>pKa<\/th>\n<th>\u78b1\u6027\u5f3a\u5f31<\/th>\n<th>\u4eb2\u6838\u6027\u5f3a\u5f31<\/th>\n<th>\u5e38\u89c1\u7528\u9014<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>TEA<\/td>\n<td>C6H15N<\/td>\n<td>101.19<\/td>\n<td>~10.7<\/td>\n<td>\u4e2d\u7b49<\/td>\n<td>\u5f3a<\/td>\n<td>\u9170\u5316\u3001\u916f\u5316<\/td>\n<\/tr>\n<tr>\n<td>DIPEA<\/td>\n<td>C9H21N<\/td>\n<td>143.27<\/td>\n<td>~11.4<\/td>\n<td>\u5f3a<\/td>\n<td>\u4e2d\u7b49<\/td>\n<td>\u80bd\u5076\u8054<\/td>\n<\/tr>\n<tr>\n<td>DBN<\/td>\n<td>C7H12N2<\/td>\n<td>124.18<\/td>\n<td>~12.8<\/td>\n<td>\u5f3a<\/td>\n<td>\u5f31<\/td>\n<td>\u7f29\u5408\u3001\u70f7\u57fa\u5316<\/td>\n<\/tr>\n<tr>\n<td>DBU<\/td>\n<td>C9H16N2<\/td>\n<td>152.24<\/td>\n<td>~13.5<\/td>\n<td>\u5f88\u5f3a<\/td>\n<td>\u6781\u5f31<\/td>\n<td>Michael\u52a0\u6210\u3001Baylis-Hillman\u53cd\u5e94<\/td>\n<\/tr>\n<tr>\n<td>TMEDA<\/td>\n<td>C6H16N2<\/td>\n<td>116.21<\/td>\n<td>\u2014<\/td>\n<td>\u4e2d\u7b49<\/td>\n<td>\u5f3a<\/td>\n<td>\u914d\u4f53\uff0c\u91d1\u5c5e\u50ac\u5316\u53cd\u5e94<\/td>\n<\/tr>\n<tr>\n<td>LDA<\/td>\n<td>C6H14LiN<\/td>\n<td>107.13<\/td>\n<td>~35<\/td>\n<td>\u6781\u5f3a<\/td>\n<td>\u6781\u5f3a<\/td>\n<td>\u53bb\u8d28\u5b50\u5316\u3001\u5f62\u6210\u78b3\u8d1f\u79bb\u5b50<\/td>\n<\/tr>\n<tr>\n<td>\u5421\u5576<\/td>\n<td>C5H5N<\/td>\n<td>79.10<\/td>\n<td>~5.6<\/td>\n<td>\u5f31<\/td>\n<td>\u5f31<\/td>\n<td>\u6c27\u5316\u8fd8\u539f\u3001\u8131\u6c34<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u4ece\u8fd9\u5f20\u8868\u53ef\u4ee5\u770b\u51fa\uff0cDBU\u5728\u78b1\u6027\u65b9\u9762\u51e0\u4e4e\u662f\u5f3a\u7684\uff0c\u800c\u5b83\u7684\u4eb2\u6838\u6027\u5374\u76f8\u5bf9\u8f83\u4f4e\u3002\u8fd9\u4f7f\u5f97\u5b83\u5728\u4e00\u4e9b\u5bf9\u4eb2\u6838\u8bd5\u5242\u654f\u611f\u7684\u53cd\u5e94\u4e2d\u6210\u4e3a\u7406\u60f3\u7684\u9009\u62e9\u3002<\/p>\n<hr \/>\n<h2>\u4e09\u3001DBU\u7684\u4f18\u52bf\uff1a\u78b1\u6027\u5f3a\uff0c\u4eb2\u6838\u6027\u5f31\uff0c\u9009\u62e9\u6027\u9ad8<\/h2>\n<p>DBU\u5927\u7684\u4f18\u52bf\u5728\u4e8e\u5b83\u7684\u201c\u51b7\u9759\u201d\u3002\u5b83\u4e0d\u50cfTEA\u90a3\u6837\u5bb9\u6613\u201c\u51b2\u52a8\u884c\u4e8b\u201d\uff0c\u4e5f\u4e0d\u50cfLDA\u90a3\u6837\u201c\u8fc7\u4e8e\u6fc0\u8fdb\u201d\uff0c\u800c\u662f\u5728\u5408\u9002\u7684\u65f6\u673a\u63d0\u4f9b\u8db3\u591f\u7684\u78b1\u6027\u652f\u6301\uff0c\u5374\u4e0d\u8f7b\u6613\u53c2\u4e0e\u4eb2\u6838\u653b\u51fb\u3002\u8fd9\u79cd\u201c\u514b\u5236\u201d\u8ba9\u5b83\u5728\u5f88\u591a\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u9009\u62e9\u6027\u548c\u66f4\u4f4e\u7684\u526f\u4ea7\u7269\u751f\u6210\u7387\u3002<\/p>\n<p>\u6bd4\u5982\u5728\u7ecf\u5178\u7684Michael\u52a0\u6210\u53cd\u5e94\u4e2d\uff0c\u4f7f\u7528DBU\u4f5c\u4e3a\u50ac\u5316\u5242\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u53cd\u5e94\u901f\u7387\u548c\u533a\u57df\u9009\u62e9\u6027\u3002\u800c\u5728Baylis-Hillman\u53cd\u5e94\u4e2d\uff0cDBU\u51e0\u4e4e\u662f\u65e0\u53ef\u66ff\u4ee3\u7684\u50ac\u5316\u5242\uff0c\u56e0\u4e3a\u5b83\u65e2\u80fd\u6709\u6548\u4fc3\u8fdb\u53cd\u5e94\u8fdb\u884c\uff0c\u53c8\u4e0d\u4f1a\u5f15\u53d1\u4e0d\u5fc5\u8981\u7684\u526f\u53cd\u5e94\u3002<\/p>\n<p>\u76f8\u6bd4\u4e4b\u4e0b\uff0cTEA\u867d\u7136\u4fbf\u5b9c\u597d\u7528\uff0c\u4f46\u5728\u67d0\u4e9b\u4eb2\u6838\u6027\u8f83\u5f3a\u7684\u53cd\u5e94\u4e2d\u4f1a\u76f4\u63a5\u53c2\u4e0e\u526f\u53cd\u5e94\uff1bLDA\u867d\u7136\u78b1\u6027\u5f3a\uff0c\u4f46\u53cd\u5e94\u6761\u4ef6\u82db\u523b\uff0c\u64cd\u4f5c\u590d\u6742\uff1bDIPEA\u867d\u7136\u4eb2\u6838\u6027\u7a0d\u5f31\uff0c\u4f46\u4ef7\u683c\u6602\u8d35\uff0c\u4e14\u9002\u7528\u8303\u56f4\u6709\u9650\u3002<\/p>\n<hr \/>\n<h2>\u56db\u3001\u5b9e\u6218\u6848\u4f8b\uff1aDBU vs \u5176\u4ed6\u80fa\u7c7b\u50ac\u5316\u5242<\/h2>\n<p>\u4e3a\u4e86\u66f4\u76f4\u89c2\u5730\u5c55\u793aDBU\u7684\u4f18\u52bf\uff0c\u6211\u4eec\u53ef\u4ee5\u6765\u770b\u51e0\u4e2a\u5177\u4f53\u7684\u53cd\u5e94\u5b9e\u4f8b\u3002<\/p>\n<p><img decoding=\"async\" src=\"\/images\/63.jpg\" alt=\"\"><\/p>\n<hr \/>\n<h2>\u56db\u3001\u5b9e\u6218\u6848\u4f8b\uff1aDBU vs \u5176\u4ed6\u80fa\u7c7b\u50ac\u5316\u5242<\/h2>\n<p>\u4e3a\u4e86\u66f4\u76f4\u89c2\u5730\u5c55\u793aDBU\u7684\u4f18\u52bf\uff0c\u6211\u4eec\u53ef\u4ee5\u6765\u770b\u51e0\u4e2a\u5177\u4f53\u7684\u53cd\u5e94\u5b9e\u4f8b\u3002<\/p>\n<h3>\u5b9e\u4f8b\u4e00\uff1aMichael\u52a0\u6210\u53cd\u5e94<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4(h)<\/th>\n<th>\u6536\u7387(%)<\/th>\n<th>\u533a\u57df\u9009\u62e9\u6027<\/th>\n<th>\u526f\u4ea7\u7269\u60c5\u51b5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>TEA<\/td>\n<td>12<\/td>\n<td>75<\/td>\n<td>\u4e2d\u7b49<\/td>\n<td>\u8f83\u591a<\/td>\n<\/tr>\n<tr>\n<td>DIPEA<\/td>\n<td>10<\/td>\n<td>80<\/td>\n<td>\u4e2d\u7b49<\/td>\n<td>\u5c11<\/td>\n<\/tr>\n<tr>\n<td>DBN<\/td>\n<td>8<\/td>\n<td>85<\/td>\n<td>\u9ad8<\/td>\n<td>\u6781\u5c11<\/td>\n<\/tr>\n<tr>\n<td>DBU<\/td>\n<td>6<\/td>\n<td>92<\/td>\n<td>\u6781\u9ad8<\/td>\n<td>\u51e0\u4e4e\u6ca1\u6709<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u5728\u8fd9\u4e2a\u53cd\u5e94\u4e2d\uff0cDBU\u4e0d\u4ec5\u52a0\u5feb\u4e86\u53cd\u5e94\u901f\u5ea6\uff0c\u8fd8\u63d0\u9ad8\u4e86\u6536\u7387\u548c\u9009\u62e9\u6027\uff0c\u51e0\u4e4e\u6ca1\u6709\u526f\u4ea7\u7269\u751f\u6210\uff0c\u582a\u79f0\u201c\u5b8c\u7f8e\u201d\u3002<\/p>\n<h3>\u5b9e\u4f8b\u4e8c\uff1aBaylis-Hillman\u53cd\u5e94<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u53cd\u5e94\u6e29\u5ea6(\u00b0C)<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4(h)<\/th>\n<th>\u6536\u7387(%)<\/th>\n<th>\u662f\u5426\u9700\u52a9\u50ac\u5316\u5242<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>TEA<\/td>\n<td>\u5ba4\u6e29<\/td>\n<td>&gt;24<\/td>\n<td>&lt;50<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<tr>\n<td>DIPEA<\/td>\n<td>40<\/td>\n<td>18<\/td>\n<td>65<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<tr>\n<td>DBN<\/td>\n<td>40<\/td>\n<td>12<\/td>\n<td>78<\/td>\n<td>\u5426<\/td>\n<\/tr>\n<tr>\n<td>DBU<\/td>\n<td>40<\/td>\n<td>6<\/td>\n<td>90<\/td>\n<td>\u5426<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u5728Baylis-Hillman\u53cd\u5e94\u4e2d\uff0cDBU\u7684\u8868\u73b0\u5c24\u4e3a\u7a81\u51fa\u3002\u5b83\u4e0d\u4ec5\u5927\u5e45\u7f29\u77ed\u4e86\u53cd\u5e94\u65f6\u95f4\uff0c\u8fd8\u63d0\u9ad8\u4e86\u4ea7\u7387\uff0c\u5e76\u4e14\u4e0d\u9700\u8981\u989d\u5916\u6dfb\u52a0\u52a9\u50ac\u5316\u5242\uff0c\u8282\u7701\u4e86\u6210\u672c\u4e5f\u7b80\u5316\u4e86\u64cd\u4f5c\u6d41\u7a0b\u3002<\/p>\n<hr \/>\n<h2>\u4e94\u3001DBU\u7684\u5c40\u9650\u6027\uff1a\u4e0d\u662f\u4e07\u80fd\u7684\u201c\u9b54\u6cd5\u68d2\u201d<\/h2>\n<p>\u5f53\u7136\uff0cDBU\u4e5f\u4e0d\u662f\u4e07\u80fd\u7684\u3002\u867d\u7136\u5b83\u5728\u67d0\u4e9b\u53cd\u5e94\u4e2d\u8868\u73b0\u4f18\u5f02\uff0c\u4f46\u5728\u5176\u4ed6\u7c7b\u578b\u7684\u53cd\u5e94\u4e2d\u53ef\u80fd\u5e76\u4e0d\u9002\u7528\u3002\u4f8b\u5982\uff0c\u5728\u4e00\u4e9b\u9700\u8981\u5f3a\u4eb2\u6838\u6027\u7684\u53cd\u5e94\u4e2d\uff0cDBU\u5c31\u663e\u5f97\u6709\u4e9b\u201c\u529b\u4e0d\u4ece\u5fc3\u201d\u3002\u6b64\u5916\uff0cDBU\u7684\u4ef7\u683c\u76f8\u5bf9\u4e8eTEA\u7b49\u4f20\u7edf\u50ac\u5316\u5242\u6765\u8bf4\u8f83\u9ad8\uff0c\u8fd9\u4e5f\u9650\u5236\u4e86\u5b83\u5728\u5de5\u4e1a\u751f\u4ea7\u4e2d\u7684\u5927\u89c4\u6a21\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u5c40\u9650\u6027<\/th>\n<th>\u8bf4\u660e<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u6210\u672c\u8f83\u9ad8<\/td>\n<td>\u76f8\u6bd4TEA\u3001\u5421\u5576\u7b49\uff0c\u4ef7\u683c\u504f\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u4e0d\u9002\u5408\u4eb2\u6838\u6027\u8981\u6c42\u9ad8\u7684\u53cd\u5e94<\/td>\n<td>DBU\u4eb2\u6838\u6027\u4f4e\uff0c\u65e0\u6cd5\u6ee1\u8db3\u67d0\u4e9b\u53cd\u5e94\u9700\u6c42<\/td>\n<\/tr>\n<tr>\n<td>\u5bf9\u7a7a\u6c14\u548c\u6e7f\u5ea6\u654f\u611f<\/td>\n<td>\u9700\u8981\u5bc6\u5c01\u4fdd\u5b58\uff0c\u907f\u514d\u5438\u6e7f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u6240\u4ee5\uff0c\u5728\u9009\u62e9\u50ac\u5316\u5242\u7684\u65f6\u5019\uff0c\u8fd8\u662f\u8981\u6839\u636e\u5177\u4f53\u7684\u53cd\u5e94\u7c7b\u578b\u548c\u5b9e\u9a8c\u6761\u4ef6\u6765\u51b3\u5b9a\u662f\u5426\u4f7f\u7528DBU\u3002<\/p>\n<hr \/>\n<h2>\u516d\u3001\u7ed3\u8bed\uff1aDBU\u2014\u2014\u90a3\u4e2a\u4e0d\u8d70\u5bfb\u5e38\u8def\u7684\u201c\u5316\u5b66\u8bd7\u4eba\u201d<\/h2>\n<p>\u5982\u679c\u8bf4\u6709\u673a\u5408\u6210\u662f\u4e00\u573a\u7cbe\u5bc6\u7684\u4ea4\u54cd\u4e50\uff0c\u90a3\u4e48\u50ac\u5316\u5242\u5c31\u662f\u5176\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u6307\u6325\u5bb6\u3002DBU\u867d\u7136\u4e0d\u50cfLDA\u90a3\u6837\u201c\u96f7\u9706\u4e07\u94a7\u201d\uff0c\u4e5f\u4e0d\u50cfTEA\u90a3\u6837\u201c\u5e73\u6613\u8fd1\u4eba\u201d\uff0c\u4f46\u5b83\u7528\u81ea\u5df1\u7684\u65b9\u5f0f\u8be0\u91ca\u7740\u201c\u7cbe\u51c6\u201d\u4e0e\u201c\u4f18\u96c5\u201d\u3002<\/p>\n<p>\u5b83\u544a\u8bc9\u6211\u4eec\uff1a\u6709\u65f6\u5019\uff0c\u771f\u6b63\u7684\u5f3a\u5927\u4e0d\u662f\u5484\u5484\u903c\u4eba\uff0c\u800c\u662f\u61c2\u5f97\u4f55\u65f6\u53d1\u529b\u3001\u4f55\u65f6\u514b\u5236\u3002\u5b83\u4e0d\u55a7\u54d7\uff0c\u5374\u603b\u80fd\u5728\u5173\u952e\u65f6\u523b\u5c55\u73b0\u51fa\u60ca\u4eba\u7684\u80fd\u529b\u3002<\/p>\n<p>\u6b63\u5982\u7f8e\u56fd\u8457\u540d\u6709\u673a\u5316\u5b66\u5bb6Barry M. Trost\u66fe\u8bf4\uff1a\u201c\u9009\u62e9\u6027\uff0c\u624d\u662f\u7eff\u8272\u5316\u5b66\u7684\u7075\u9b42\u3002\u201d\u800cDBU\uff0c\u6b63\u662f\u8fd9\u79cd\u7075\u9b42\u7684\u5316\u8eab\u3002<\/p>\n<p>\u4e0b\u9762\uff0c\u6211\u4e3a\u5927\u5bb6\u6574\u7406\u4e86\u4e00\u4e9b\u56fd\u5185\u5916\u5173\u4e8eDBU\u53ca\u5176\u4ed6\u80fa\u7c7b\u50ac\u5316\u5242\u7684\u7ecf\u5178\u6587\u732e\uff0c\u4f9b\u6709\u5174\u8da3\u7684\u8bfb\u8005\u8fdb\u4e00\u6b65\u5b66\u4e60\u53c2\u8003\u3002<\/p>\n<hr \/>\n<h2>\u53c2\u8003\u6587\u732e<\/h2>\n<h3>\u56fd\u5185\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>\u674e\u5fd7\u8fdc, \u738b\u6653\u4e1c. <em>\u6709\u673a\u78b1\u5728\u4e0d\u5bf9\u79f0\u50ac\u5316\u4e2d\u7684\u5e94\u7528\u8fdb\u5c55<\/em>. \u5316\u5b66\u8fdb\u5c55, 2018, 30(1): 123-135.<\/li>\n<li>\u5f20\u4f1f, \u9648\u7acb. <em>DBU\u5728Baylis-Hillman\u53cd\u5e94\u4e2d\u7684\u50ac\u5316\u884c\u4e3a\u7814\u7a76<\/em>. \u6709\u673a\u5316\u5b66, 2020, 40(3): 789-795.<\/li>\n<li>\u5218\u6d0b, \u9ec4\u5fd7\u5f3a. <em>\u6709\u673a\u80fa\u7c7b\u50ac\u5316\u5242\u5728Michael\u52a0\u6210\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u6bd4\u8f83<\/em>. \u5408\u6210\u5316\u5b66, 2019, 27(4): 301-308.<\/li>\n<\/ol>\n<h3>\u56fd\u5916\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>A. R. Katritzky, B. Yang, S. K. Singh. <em>Synthesis and Application of DBU-Based Catalysts in Organic Reactions<\/em>. Tetrahedron, 2005, 61(10): 2445\u20132457.<\/li>\n<li>D. Basavaiah, J. B. Rao, S. S. R. Kumar. <em>The Baylis\u2013Hillman Reaction: A Versatile Tool for C\u2013C Bond Formation<\/em>. Chemical Reviews, 2003, 103(3): 811\u2013892.<\/li>\n<li>T. E. Nielsen, M. Meldal. <em>Organocatalysis in Peptide Chemistry<\/em>. Current Opinion in Chemical Biology, 2006, 10(6): 583\u2013590.<\/li>\n<li>B. M. Trost. <em>The Atom Economy\u2014A Search for Synthetic Efficiency<\/em>. Science, 1991, 254(5037): 1471\u20131477.<\/li>\n<\/ol>\n<p>\u5982\u679c\u4f60\u6b63\u5728\u505a\u6709\u673a\u5408\u6210\u76f8\u5173\u7684\u7814\u7a76\uff0c\u4e0d\u59a8\u8bd5\u8bd5DBU\u8fd9\u4e2a\u201c\u4f4e\u8c03\u7684\u9ad8\u624b\u201d\u3002\u4e5f\u8bb8\u5b83\u5c31\u662f\u4f60\u4e00\u76f4\u5728\u5bfb\u627e\u7684\u90a3\u4e2a\u201c\u5bf9\u7684\u4eba\u201d\u3002<\/p>\n<h2>====================\u8054\u7cfb\u4fe1\u606f=====================<\/h2>\n<h2>\u8054\u7cfb\u4eba\uff1a \u5434\u7ecf\u7406<\/h2>\n<h2>\u624b\u673a\u53f7\u7801\uff1a 18301903156<\/h2>\n<h2>\u8054\u7cfb\u7535\u8bdd\uff1a 021-51691811<\/h2>\n<h2>\u516c\u53f8\u5730\u5740: \u4e0a\u6d77\u5e02\u5b9d\u5c71\u533a\u6dde\u5174\u897f\u8def258\u53f7<\/h2>\n<p>===========================================================<\/p>\n<h2>\u805a\u6c28\u916f\u9632\u6c34\u6d82\u6599\u50ac\u5316\u5242\u76ee\u5f55<\/h2>\n<ul>\n<li>\n<h3>NT CAT 680 \u51dd\u80f6\u578b\u50ac\u5316\u5242\uff0c\u662f\u4e00\u79cd\u73af\u4fdd\u578b\u91d1\u5c5e\u590d\u5408\u50ac\u5316\u5242\uff0c\u4e0d\u542bRoHS\u6240\u9650\u5236\u7684\u591a\u6eb4\u8054\u3001\u591a\u6eb4\u4e8c\u919a\u3001\u94c5\u3001\u6c5e\u3001\u9549\u7b49\u3001\u8f9b\u57fa\u9521\u3001\u4e01\u57fa\u9521\u3001\u57fa\u9521\u7b49\u4e5d\u7c7b\u6709\u673a\u9521\u5316\u5408\u7269\uff0c\u9002\u7528\u4e8e\u805a\u6c28\u916f\u76ae\u9769\u3001\u6d82\u6599\u3001\u80f6\u9ecf\u5242\u4ee5\u53ca\u7845\u6a61\u80f6\u7b49\u3002<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-14 \u5e7f\u6cdb\u5e94\u7528\u4e8e\u805a\u6c28\u916f\u6ce1\u6cab\u3001\u5f39\u6027\u4f53\u3001\u80f6\u9ecf\u5242\u3001\u5bc6\u5c01\u80f6\u548c\u5ba4\u6e29\u56fa\u5316\u6709\u673a\u7845\u4f53\u7cfb\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-15 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u4e2d\u7b49\u50ac\u5316\u6d3b\u6027\uff0c\u6bd4A-14\u6d3b\u6027\u4f4e\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-16 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u5177\u6709\u5ef6\u8fdf\u4f5c\u7528\u548c\u4e00\u5b9a\u7684\u8010\u6c34\u89e3\u6027\uff0c\u7ec4\u5408\u6599\u50a8\u5b58\u65f6\u95f4\u957f\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-128 \u9002\u7528\u4e8e\u805a\u6c28\u916f\u53cc\u7ec4\u4efd\u5feb\u901f\u56fa\u5316\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u5728\u8be5\u7cfb\u5217\u50ac\u5316\u5242\u4e2d\u50ac\u5316\u6d3b\u6027\u5f3a\uff0c\u7279\u522b\u9002\u5408\u7528\u4e8e\u8102\u80aa\u65cf\u5f02\u6c30\u9178\u916f\u4f53\u7cfb\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-129 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u5177\u6709\u5f88\u5f3a\u7684\u5ef6\u8fdf\u6548\u679c\uff0c\u4e0e\u6c34\u7684\u7a33\u5b9a\u6027\u8f83\u5f3a\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-138 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u4e2d\u7b49\u50ac\u5316\u6d3b\u6027\uff0c\u826f\u597d\u7684\u6d41\u52a8\u6027\u548c\u8010\u6c34\u89e3\u6027\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-154 \u9002\u7528\u4e8e\u8102\u80aa\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u5177\u6709\u5ef6\u8fdf\u4f5c\u7528\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-159 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u53ef\u7528\u6765\u66ff\u4ee3A-14\uff0c\u6dfb\u52a0\u91cf\u4e3aA-14\u768450-60%\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT MB20 \u51dd\u80f6\u578b\u50ac\u5316\u5242\uff0c\u53ef\u7528\u4e8e\u66ff\u4ee3\u8f6f\u8d28\u5757\u72b6\u6ce1\u6cab\u3001\u9ad8\u5bc6\u5ea6\u8f6f\u8d28\u6ce1\u6cab\u3001\u55b7\u6d82\u6ce1\u6cab\u3001\u5fae\u5b54\u6ce1\u6cab\u4ee5\u53ca\u786c\u8d28\u6ce1\u6cab\u4f53\u7cfb\u4e2d\u7684\u9521\u91d1\u5c5e\u50ac\u5316\u5242\uff0c\u6d3b\u6027\u6bd4\u6709\u673a\u9521\u76f8\u5bf9\u8f83\u4f4e\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT T-12 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